There will be several next generation reactor designs, just like there were for Gen-II. But solving the twin challenges of limited uranium reserves and spent nuclear fuel (a mix of actinides) burn up will be absolutely central. Transatomic Power wants to build a molten salt reactor which achieves these.
Transatomic Power (TAP) is developing an advanced molten salt reactor that generates clean, passively safe, proliferation-resistant, and low-cost nuclear power. This reactor can consume the spent nuclear fuel (SNF) generated by commercial light water reactors or use freshly mined uranium at enrichment levels as low as 1.8% U-235. It achieves actinide burnups as high as 96%, and can generate up to 75 times more electricity per ton of mined uranium than a light-water reactor.